We’re excited to share Carolina Natal’s latest article, “High-Yield Production and Cost-Effective Purification of an Alkali-Resistant Hexameric Protein A Variant for Antibody Affinity Chromatography”, now published in Biotechnology Journal.
We present a scalable method for producing the antibody-binding ligand Z6AlkC, a six-repeat, alkali-resistant Protein A–derived Z domain with a terminal cysteine. The ligand was produced at high yield via extracellular secretion in bioreactors and subsequently purified by high-productivity ultradiafiltration with low water consumption.
Check out the full article: https://doi.org/10.1002/biot.70247
For more information about the PURE project, go to PURE website: https://pure-fetopen.eu/
